LET'S WATCH REGENERATION
We study how epithelial tissues generate the right cells in the right places as they renew and regenerate during adulthood.
WHAT WE DO
Our lab focuses on two of the most dynamic organ systems in mammals: the small intestine and the uterus. The intestinal epithelium is in a constant state of flux, replacing almost all of its cells every 3-5 days, and can rapidly regenerate its diverse cell types upon damage. The human uterine lining (endometrium) undergoes dramatic tissue remodeling each month over the menstrual cycle, followed by shedding during menstruation and subsequent repair, ultimately regenerating ~400 times over the reproductive lifespan. Together, these systems provide powerful complementary models to reveal unifying principles of regeneration, as well as to identify key aspects of organ-specific physiology.
WHY WE DO IT
Defining the molecular mechanisms of intestinal and uterine regeneration is essential to identify new strategies to treat and manage widespread conditions such as cancers, IBD, endometriosis, and infertility. Understanding the mechanisms that drive and constrain regeneration will also allow us to harness these mechanisms for the precise repair of tissues damaged by trauma or impaired by aging.
HOW WE DO IT
We use high-resolution live microscopy to watch and perturb regeneration in real time, and use a variety of genetic, molecular, and cell biological approaches to mechanistically dissect these processes over single-cell and tissue length scales.
We are looking for students and postdocs to join our team! We are excited to help support you in doing cool science, learning new things, and defining and achieving your professional goals.
Harvard undergraduate students
Please email Kara your CV and a short description of your research interests.
Harvard graduate students
Please email Kara about a rotation.
Please email Kara your CV, a short description of your research interests, and contact information for 3 references.
We are grateful to our funders for their support